Perkembangan Bayi Tabung: Blastocyst Culture ~ Bayi Tabung / in vitro fertilization

Jumat, 21 September 2007

Perkembangan Bayi Tabung: Blastocyst Culture


Blastocyst culture adalah sebuah tehnik baru dalam prosedur in vitro fertilization dimana embrio yang ditanamkan adalah yang sudah berumur 5-6 hari, 2 hari lebih lama dari IVF standar. Penambahan waktu ini mempermudah memilih embrio yang lebih sehat dan memiliki kemungkinan keberhasilan yang lebih tinggi. Kesempatan untuk kelahiran ganda (kembar, kembar tiga) pun lebih dapat diminimalkan.

Tehnik IVF pada umumnya menggunakan embrio yang berumur 3 hari dengan tingkat sel 6-10 lalu kemudian dipindahkan kembali ke dalam uterus. Jika embrio dibiarkan tumbuh selama 5 hari atau lebih di laboratorium, maka embrio tersebut akan menjadi blastosis dengan tingkat perkembangan sel 50

Keunggulan Blastosis

Sel dari embrio yang berumur lebih dari 3 hari akan mulai untuk membelah setelah distimulasikan dengan sinyal yang dapat ditemukan dalam sel telur yang sudah matang. Embrio memiliki genom yang unik yang belum diaktifkan. Setelah 5 hari, genom tersebut akan aktif dan membelah lalu tumbuh berdasarkan sinyal dari genetiknya sendiri. Jika embrio telah sampai pada tahap blastosis maka embrio tersebut telah melalui masalah pertama dalam proses perkembangannya. Proses pengaktifan gen ini tidak dapat dievaluasi jika embrio masih berumur 3 hari. Dalam siklus reproduksi normal, hari ke-3 (6-10 sel) embrio berada dalam tuba fallopi. Setelah 5 hari, blastosis akan tiba di saluran uterus dan memulai proses implantasi. Pemindahan blastosis yang berumur 5 hari lebih bersifat alamiah dalam prosesnya jika dilihat dari padangan psikologi.

Sistem Pemindahan Blastosis belum banyak digunakan karena proses pengaktifan gen-nya memerlukan media kultur dan lingkungan yang khusus.

Berbeda dari proses standar IVF, proses blastosis ini memerlukan embrio yang berumur 5 hari atau lebih. Tapi jika dilihat dari penangan si pasien, maka secara umum prosedur yang digunakan tidak berbeda jauh dari standar IVF.

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